Very low amounts of opioid analgesics are already detected in human milk. The developmental and wellness great things about breastfeeding really should be considered combined with the mother's clinical need to have for DILAUDID INJECTION and any likely adverse results about the breastfed infant from DILAUDID INJECTION or from the underlying maternal affliction.
The subsequent severe adverse reactions are explained, or explained in increased detail, in other sections:
If a patient is suspected to generally be going through OIH, thoroughly look at appropriately lowering the dose of the current opioid analgesic or opioid rotation (safely switching the patient to a unique opioid moiety) [see DOSAGE AND ADMINISTRATION, WARNINGS AND PRECAUTIONS].
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The pharmacokinetics of hydromorphone in clients with extreme hepatic impairment hasn't been studied. An additional rise in Cmax and AUC of hydromorphone With this team is expected and should be taken into consideration when selecting a commencing dose [see Medical Pharmacology (12.3].
For anyone who is having surgical procedures, like dental surgical procedure, notify the medical professional or dentist that you are utilizing hydromorphone injection.
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Inform sufferers of the risk of everyday living-threatening respiratory despair, which includes facts that the chance is finest when starting DILAUDID INJECTION or when the dosage is increased, and that it can happen even at recommended dosages.
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The concomitant usage of anticholinergic medications could increase possibility of urinary retention and/or extreme constipation, which may result in paralytic ileus.
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Hydromorphone hydrochloride can be a white or Nearly white crystalline powder that may be freely soluble in drinking water, pretty a bit soluble in ethanol (ninety six%), and virtually insoluble in methylene chloride.
The concomitant use of anticholinergic drugs might increase threat of urinary retention and/or significant constipation, which may lead to paralytic ileus.
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